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Pharmacology

Nanotechnological medicine formulation for steroids

The aim of the research was to develop a steroid formulation especially for inflammatory cells (macrophage cells). Macrophages are phagocytosing the particles of size beyond 1OOnm in their environment and then build them down. For the preparation of a steroid composition preferentially acting on macrophages, chemically modified silica bead-based particles were prepared in a size range of about 1 to about 15 micrometres, wherein the steroidal active ingredient is in the bound form, and the bound agent is exacerbated in acidic environments.

Methods and materials for reducing ischemia-reperfusion injury

Ischemia is a restriction in blood supply to tissues, which causes a shortage of elements needed for the tissues to survive such as oxygen and glucose. Surprisingly, the restoration of the physiological blood flow (e.g., reperfusion) causes further tissue lesions in many cases. These local and systemic inflammatory responses caused by reperfusion following ischemia can be associated with several clinical manifestations, including lung failure, renal insufficiency, cardiac arrhythmias, acute heart failure etc. These clinical complications can significantly worsen the survival chances of patients.

 

In vitro Lung Tissue

Acute and chronic lung diseases are one of the major causes of morbidity and mortality world wide. If heart-lung transplant is needed, patients rarely survive. If molecular mechanisms leading to lung regeneration were known, or drug targets were more easily identified in human lung tissue and lung disease models, less invasive therapies could be developed. In the model physiological interactions, surfactant production, drug transport via specific transporters, regeneration processes can all be investigated. The role of the innate immune system in lung parenchyma damage can also be studied.

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